![]() In spite of the widespread use of these techniques, the use of fluorescent labels also poses some risks and has several drawbacks. ![]() The surface modification of cells with nanoparticles or the internalization of nanoparticles by cells is usually monitored with fluorescence-based techniques, such as flow cytometry and confocal microscopy. ![]() One key element in the development of cell-based delivery systems is the loading of the cell-based carrier with the nanoparticle cargo, which can be achieved either by internalization of the payload or by immobilization on the cell surface. The use of cell-based carriers allows one to enhance control over the biodistribution of drug-loaded polymers and polymer nanoparticles. Cells are attractive carriers for the transport and delivery of nanoparticulate cargo.
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